NN104 Paper, "Selecting patients for intraarterial therapy in the context of a clinical trial for neuroprotection"

Lyden P, Weymer S, Coffey C, Cudkowicz M, Berg S, O'Brien S, Fisher M, Haley EC, Khatri P, Saver J, Levine S, Levy H, Rymer M, Wechsler L, Jadhav A, McNeil E, Waddy S, Pryor K.

Selecting patients for intraarterial therapy in the context of a clinical trial for neuroprotection. Stroke. 2016; 47(12):2979-2985.

PubMed: PMC5134840

Description: 

The advent of intra-arterial neurothrombectomy (IAT) for acute ischemic stroke opens a potentially transformative opportunity to improve neuroprotection studies. Combining a putative neuroprotectant with recanalization could produce more powerful trials but could introduce heterogeneity and adverse event possibilities. We sought to demonstrate feasibility of IAT in neuroprotectant trials by defining IAT selection criteria for an ongoing neuroprotectant clinical trial.

Projects: 
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