NN106 Cyto-C

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. These tumors are often aggressive and infiltrate surrounding brain tissue. Signs and symptoms are initially non-specific. They may include headaches, personality changes, nausea, and symptoms similar to that of a stroke. Worsening of symptoms is often rapid and can progress to unconsciousness.

This research study is being conducted to prospectively evaluate the hypothesis that the overall survival time of a subject with newly diagnosed GBM tumors, treated with standard of care therapy, is a function of the CcO enzymatic activity in the tumor. In particular, tumors with high CcO activity, are associated with shorter time of overall survival when compared to tumors with low CcO activity. Standard of care therapy consists of post-surgical radiation therapy with concurrent Temozolomide followed by up to 12 cycles of adjuvant Temozolomide.

NN106 is supported by NINDS (U01 NS093663).