Serena is Professor of Neurology and Chief, Division of Neurological Infections and Global Neurology at Yale. Her clinical and translational research explores HIV in the nervous system, focusing on effects of acute HIV infection, antiretroviral treatment, and HIV cure strategies on HIV pathogenesis and persistence in the central nervous system. She collaborates with colleagues of multiple disciplines in clinical studies in urban centers in the United States and in international settings, exploring questions of inflammation, injury, and reservoirs for HIV within the central nervous system. She co-leads the International NeuroHIV Cure Consortium (https://www.inhcc.net/), currently serves on the DHHS Panel on Adult and Adolescent Antiretroviral Treatment Guidelines, and leads multiple NIH-funded projects addressing the pathobiology of NeuroHIV. She has had long term involvement in the NIH-sponsored International AIDS Clinical Trials Group (ACTG) Network, including serving as Chair of the Neurology Collaborative Science Group, as the first neuroscientist elected to the HIV Reservoirs and Eradication Transformative Science Group, and through involvement in numerous multisite clinical trials and pathogenesis studies relevant to NeuroHIV and HIV cure. She also is a neurology clinician who cares for individuals living with HIV and neurological disorders in the Nathan Smith HIV Clinic at Yale.