Over the past 3 decades, Dr. Packer’s research has focused on clinical research in pediatric brain tumors and, more recently, in addition, neurofibromatosis type 1. In his responsibilities as a neuro-oncology researcher, he has been involved in clinical trial development and translational research and has developed and led multiple clinical/translational neuro-oncology trials on a regional/national/international level. He has held multiple national leadership roles including being Chair of the Strategy Group of the Children’s Oncology Group, Chair of the Medulloblastoma Subcommittee of the Children’s Oncology Group, and neurologist to the Children’s Cancer Survivor Study. He is also the Principal Investigator at CNMC for the Pediatric Brain Tumor Consortium, a consortium developed by NIH to do translational studies in childhood brain tumors. He has similarly led multiple trials in neurofibromatosis type 1 for disease states including progressive plexiform neurofibromas and visual pathway and other gliomas. He is presently Group Chair of the Department of Defense sponsored Neurofibromatosis Clinical Trials Consortium. In addition to his research responsibilities, since 1998 he has been Director of the Neuroscience and Behavioral Medicine Center at the Children’s National Medical Center, and since 2009 has been Sr. Vice-President of Neuroscience and Behavioral Medicine at the Children’s National Medical Center, with responsibility of the clinical research, academic, and educational programs of multiple divisions including Neurology, Neurosurgery, Psychiatry, Psychology, Neuro-Psychology, Physical Medicine and Rehabilitation, and Genetics. He also serves as Director of the Brain Tumor Institute and Gilbert Neurofibromatosis Institute at the Children’s National Medical Center.