I had the good fortune to start my graduate studies in molecular biology at the beginning of a revolution in genetic technology. For the last 20 years, I have been using molecular genetic technology to study basic molecular processes and neurological disease. As a trained clinical neurologist, I have also had the opportunity to observe the onset and progression of a number of neurological diseases, including multiple sclerosis (MS) and Huntington Disease, demonstrating in a concrete way the molecular pathophysiology I have studied in the laboratory. This clinical experience not only brings home the human element of the disease, but also provides additional and important insight into its molecular pathogenesis.